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Gorgon is an interactive molecular modeling system specifically geared towards cryo-EM
and other low resolution structures of macromolecular complexes. The long term goal of
the gorgon project is to be able to address to every part of the molecular modeling pipeline
starting from the initial volumetric reconstruction of the complex all the way to the final placement of
each individual atom.
Gorgon currently provides the following feature categories:
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Visualization:
A comprehensive visualization framework for volumetric data (iso-contours,
cross-sections and solid rendering), geometric skeletons, secondary structure elements and atomic
models (PDB).
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Geometric operations:
Many geometric operations such as skeletonization (binary / grayscale and interactive), smoothing,
resampling, cropping, etc. are provided.
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Protein structure prediction:
We provide tools which allow users to find the correspondence between
predicted secondary structure elements in the sequence and the observed secondary structure elements in the
volume
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Protein backbone tracing:
The c-alpha backbone of a protein can be easily traced manually or semi-automatically
using the many supporting elements offered by Gorgon.
Gorgon is being developed as a collaboration between Washington University in St. Louis and Baylor
College of Medicine.
Acknowledgements
We would like to thank
Media and Machines Lab at
Washington University in St. Louis and
National Center for Macromolecular Imaging at
Baylor College of Medicine .
This work is supported by the NSF grants IIS-0705474, IIS-0705538 and the NCMI grant through the NIH RR002250.
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